sapping my energy; symptoms due to menopause/ seems to have become more intense; poor sleep; unable to rest, bad sleep; hot flushes; severe burning pain in arms and chest; severe burning pain in arms and chest; and today 22dec2021 only menstrual bleeding after years suddenly again; penetratingly unpleasant feeling in the heart area; i feel unwell; very tired; also tinnitus, long recovery time needed after exertion; an uncomfortable feeling in the heart area; depressive feelings, thoughts and crying a lot; crying; this is a spontaneous report received from a contactable reporter (consumer or other non hcp) from the regulatory authority-web. the reporter is the patient. regulatory number: nl-lrb-00734074 (ra). a 60 year-old female patient received bnt162b2 (comirnaty), administration date 19jun2021 (lot number: fc3098) as dose 2, single for covid-19 immunisation. relevant medical history included: "periods were problematic" (unspecified if ongoing), notes: from the time they started at age 11; "menopause" (unspecified if ongoing); "trauma" (unspecified if ongoing); "depression due to trauma" (unspecified if ongoing). the patient's concomitant medications were not reported. vaccination history included: comirnaty (dose 1), administration date: 14may2021, for covid-19 immunisation, reaction: "no adverse event". the following information was reported: postmenopausal haemorrhage (medically significant) with onset 22dec2021, outcome "unknown", described as "and today 22dec2021 only menstrual bleeding after years suddenly again"; angina pectoris (medically significant) with onset 22dec2021, outcome "unknown", described as "penetratingly unpleasant feeling in the heart area"; malaise (non-serious) with onset 22dec2021, outcome "unknown", described as "i feel unwell"; fatigue (non-serious) with onset 22dec2021, outcome "unknown", described as "very tired"; tinnitus (non-serious) with onset 22dec2021, outcome "unknown", described as "also tinnitus, long recovery time needed after exertion"; chest discomfort (non-serious) with onset 22dec2021, outcome "unknown", described as "an uncomfortable feeling in the heart area"; depressed mood (non-serious) with onset 22dec2021, outcome "unknown", described as "depressive feelings, thoughts and crying a lot"; crying (non-serious) with onset 22dec2021, outcome "unknown", described as "crying"; asthenia (non-serious), outcome "unknown", described as "sapping my energy"; menopausal symptoms (non-serious), outcome "unknown", described as "symptoms due to menopause/ seems to have become more intense"; poor quality sleep (non-serious), outcome "unknown", described as "poor sleep"; insomnia (non-serious) with onset 22dec2021, outcome "unknown", described as "unable to rest, bad sleep"; hot flush (non-serious) with onset 22dec2021, outcome "unknown", described as "hot flushes"; pain in extremity (non-serious), chest pain (non-serious) all with onset 22dec2021, outcome "unknown" and all described as "severe burning pain in arms and chest". clinical course: the patient felt sick and very tired, and on the day of reporting 22dec2021 suddenly got a period again after years. also had tinnitus, need a long recovery after exertion. a penetratingly unpleasant feeling in the heart area. depressive feelings, thoughts and lots of crying. the symptoms are sapping her energy. except for the bleeding, she already had some of the symptoms due to menopause and trauma, but it all seems to have become more intense. especially the constant feeling of exhaustion, dead tired, but can't rest. poor sleep, hot flashes that give her an intense burning pain in arms and chest. no follow-up attempts are possible. no further information is expected