heavy menstruation after menopause (2 years no menstruation), heavy blood loss, heavier than ever before; off label use; interchange of vaccine products; this is a spontaneous report received from a contactable reporter(s) (consumer or other non hcp) from the regulatory authority-web. regulatory number: nl-lrb-00737336 (ra). a 51 year-old female patient received bnt162b2 (comirnaty), administration date 07dec2021 (lot number: 1f1008a) as dose 3 (booster), single for covid-19 immunisation. relevant medical history included: "disease risk factor" (unspecified if ongoing); "menopause" (unspecified if ongoing), notes: (2 years no menstruation). previous covid-19 infection: no. the patient's concomitant medications were not reported. vaccination history included: spikevax (dose 1, 0.5 ml single; adrs: none), administration date: 12may2021, for covid-19 immunisation, reaction(s): "no adverse reaction"; spikevax (dose 2, 0.5 ml single; adverse events: fever, chills, etc), administration date: 09jun2021, for covid-19 immunisation, reaction(s): "fever", "chills". the following information was reported: off label use (medically significant) with onset 07dec2021, outcome "unknown", described as "off label use"; interchange of vaccine products (medically significant) with onset 07dec2021, outcome "unknown", described as "interchange of vaccine products"; postmenopausal haemorrhage (medically significant) with onset 23dec2021, outcome "not recovered", described as "heavy menstruation after menopause (2 years no menstruation), heavy blood loss, heavier than ever before". reporter comment: moderna vaccine (spikevax). past drug therapy moderna vaccine (spikevax): yes adrs: none date: 12may2021. past drug therapy moderna vaccine (spikevax): yes adrs: fever, chills, etc. date: 09jun2021. heavy menstruation after menopause (2 years of no menstruation) additional information adr: heavy blood loss, more than ever before. covid19 previous covid-19 infection: no. other diagnostic procedures: no no follow-up attempts are possible. no further information is expected.; reporter's comments: moderna vaccine (spikevax). past drug therapy moderna vaccine (spikevax): yes adrs: none date: 12may2021. past drug therapy moderna vaccine (spikevax): yes adrs: fever, chills, etc. date: 09jun2021. heavy menstruation after menopause (2 years of no menstruation) additional information adr: heavy blood loss, more than ever before. covid19 previous covid-19 infection: no. other diagnostic procedures: no